SPARC Levels Modulate the Capacity of Mitomycin to Inhibit the Proliferation of Human Tenon's Capsule Fibroblasts.

Yuanyuan GuoShouxiang NiWeiyan ZhouJiangping HouJiaquan Shen

Published in: Journal of ophthalmology (2020)

This study demonstrates that in HTF, (1) MMC downregulates the expression of SPARC in protein and mRNA levels; (2) SPARC depletion has synergistic effect on the antifibrotic effect of MMC; and (3) reactive oxygen species are the possible mediator in the antifibrotic effect of MMC and si-SPARC.

Keyphrases

reactive oxygen species
binding protein
endothelial cells
poor prognosis
signaling pathway
pulmonary fibrosis
long non coding rna
protein protein
small molecule