Somatic Variants in SVIL in Cerebral Aneurysms.
Pui Man Rosalind LaiJee-Yeon RyuSang-Cheol ParkBradley A GrossLawrence D DickinsonSarajune DagenMohammad Ali Aziz-SultanAlan S BoulosDaniel L BarrowH Hunt BatjerSpiros BlackburnEdward F ChangPeng Roc ChenGeoffrey P ColbyGarth Rees CosgroveCarlos A DavidArthur L DayKai U FrerichsMika NiemelaSteven G OjemannNirav J PatelXiangen ShiEdison P Valle-GilerAnthony C WangBabu G WelchEdie E ZusmanScott T WeissRose DuPublished in: Neurology. Genetics (2022)
result in the phenotypic modulation of vSMCs, which increases the susceptibility to aneurysm formation. This finding suggests a new avenue for the therapeutic intervention and prevention of cerebral aneurysms.