Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats.
Siresha BathinaUndurti N DasPublished in: Lipids in health and disease (2018)
These results suggest that STZ induces pancreatic β cell apoptosis by enhancing inflammation. Significant alterations in the expression brain insulin signaling and cell survival pathways seen in brain of STZ-treated animals implies that alterations neuronal apoptosis may have a role in altered glucose homeostasis seen in type 2 DM that may also explain the increased incidence of cognitive dysfunction seen in them.
Keyphrases
- diabetic rats
- oxidative stress
- resting state
- white matter
- cerebral ischemia
- glycemic control
- functional connectivity
- type diabetes
- poor prognosis
- cell proliferation
- cell death
- endoplasmic reticulum stress
- high glucose
- cardiovascular disease
- cell cycle arrest
- blood glucose
- long non coding rna
- blood pressure
- endothelial cells
- weight loss
- drug induced
- adipose tissue
- blood brain barrier
- pi k akt
- diabetic nephropathy