Regimen on Dnaja3 haploinsufficiency mediated sarcopenic obesity with imbalanced mitochondrial homeostasis and lipid metabolism.

Yu-Ning FannWan-Huai TeoHsin-Chen LeeChen-Chung LiaoYeou-Guang TsayTung-Fu HuangJeng-Fan Lo

Published in: Journal of cachexia, sarcopenia and muscle (2024)

Muscular Dnaja3 haploinsufficiency dysregulates mitochondrial function and lipid metabolism then leads to sarcopenic obesity. GMI emerges as a therapeutic regimen for sarcopenic obesity treatment through DNAJA3 activation.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
oxidative stress
fatty acid
adipose tissue
physical activity
high intensity