Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats.
Reihaneh EbrahimiMohammad Reza SepandSeyed Afshin SeyednejadAmeneh OmidiMostafa AkbarianiMaryam GholamiOmid SabzevariPublished in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2019)
EA protects rats against MTX-induced apoptosis and mitochondrial dysfunction via up-Regulating Nrf2 and HO-1 expression and inhibiting the NF-κB signaling pathway. Therefore, EA may protect patients against MTX-induced hepatotoxicity and encourage its clinical application. Graphical abstract Beneficial effect of Ellagic acid (EA) on Methotrexate (MTX)-induced liver injury: molecular mechanism.
Keyphrases
- induced apoptosis
- signaling pathway
- pi k akt
- oxidative stress
- poor prognosis
- epithelial mesenchymal transition
- end stage renal disease
- endoplasmic reticulum stress
- diabetic rats
- ejection fraction
- high dose
- chronic kidney disease
- newly diagnosed
- drug induced
- prognostic factors
- immune response
- patient reported outcomes
- inflammatory response
- nuclear factor
- patient reported