Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer.

Xiaoxuan XiaWilliam Ka Kei WuSunny Hei WongDabin LiuThomas Ngai Yeung KwongGeicho NakatsuPearlly S YanYu-Ming ChuangMichael Wing-Yan ChanOlabisi Oluwabukola CokerZigui ChenYun Kit YeohLiuyang ZhaoXiansong WangWing Yin ChengMatthew Tak Vai ChanPaul Kay Sheung ChanJoseph Jao Yiu SungMaggie Haitian WangJun Yu

Published in: Microbiome (2020)

Our integrative analysis revealed previously unknown epigenetic regulation of TSGs in host cells through inducing DNA methyltransferase by F. nucleatum and H. hathewayi, and established the latter as CRC-promoting bacteria. Video abstract.

Keyphrases

induced apoptosis
dna methylation
cell cycle arrest
genome wide
circulating tumor
gene expression
single molecule
transcription factor
gram negative
signaling pathway
cell proliferation
genome wide identification
nucleic acid