Role of brain-derived neurotrophic factor in the pathogenesis of distention-associated abdominal pain in bowel obstruction.
Y FuY M LinJohn H WinstonR RadhakrishnanL-Y M HuangXuan-Zheng ShiPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)
Mechanical stress-induced expression of BDNF in colon SMC plays a critical role in visceral hypersensitivity in BO by suppressing A-type K+ currents and gene expression in sensory nerve. These findings help to identify therapeutic targets for distention-associated abdominal pain in the gut.