DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults.
Mark A BurtonEmma S GarrattMatthew O HewittHanan Y SharkhElie AntounLeo D WestburyElaine M DennisonNicholas C HarveyCyrus CooperJulia L MacIsaacMichael S KoborHarnish P PatelKeith M GodfreyKaren A LillycropPublished in: Skeletal muscle (2023)
These findings suggest that insulin resistance is associated with differential DNA methylation in human primary myoblasts with both muscle mass and body composition making a significant contribution to the methylation changes associated with IR.
Keyphrases
- dna methylation
- body composition
- genome wide
- insulin resistance
- type diabetes
- gene expression
- resistance training
- bone mineral density
- endothelial cells
- signaling pathway
- metabolic syndrome
- physical activity
- adipose tissue
- high fat diet
- copy number
- induced pluripotent stem cells
- skeletal muscle
- glycemic control
- pluripotent stem cells
- postmenopausal women
- weight loss