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Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer.

Sehui KimJi-Young JangJaemoon KohDohee KwonYoung A KimJin Chul PaengChan-Young OckBhumsuk KeamMiso KimTae Min KimDae Seog HeoDoo Hyun ChungYoon Kyung Jeon
Published in: Journal of experimental & clinical cancer research : CR (2019)
PD-L1 enhances glycolysis in NSCLC by upregulating HK2, which might dampen anti-tumor immunity. PD-L1 may contribute to NSCLC oncogenesis by inducing metabolic reprogramming and immune checkpoint.
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