Possible Underlying Mechanisms for the Renoprotective Effect of Retinoic Acid-Pretreated Wharton's Jelly Mesenchymal Stem Cells against Renal Ischemia/Reperfusion Injury.

Mai Barakat Abdelaziz M Hussein Mohamed F SalamaAmira AwadallaNashwa BarakatMohamed S SerriaMohamed El-ShafeyMohamed El SherbinyMohamed A El Adl

Published in: Cells (2022)

It is concluded that preconditioning of WJ-MSCs with ATRA may enhance their renoprotective effect. This effect could be due to the upregulation of the beta-catenin/Wnt pathway and attenuation of apoptosis, inflammation, and oxidative stress.

Keyphrases

oxidative stress
ischemia reperfusion injury
mesenchymal stem cells
umbilical cord
cell proliferation
diabetic rats
dna damage
stem cells
induced apoptosis
signaling pathway
endoplasmic reticulum stress
bone marrow
poor prognosis
long non coding rna
diabetic nephropathy
heat shock protein