Pharmacokinetics and Bioavailability Study of a Novel Smoothened Inhibitor TPB15 for Treatment of Triple-Negative Breast Cancer in Rats by High Performance Liquid Chromatography-Mass Spectrometry.
Bo-Yu ChenJia-Huan XuQian-Qing ChenHuan-Xian WuBao-Fang OuZhiwei ZhouFei XuShao-Yu WuShui-Lin XieDing-Sheng WenPublished in: European journal of drug metabolism and pharmacokinetics (2024)
. Nevertheless, the next phase of research should include formulation screening to enhance bioavailability, as well as clinical trials, metabolism pathway analysis, and assessment of potential drug-drug interactions.
Keyphrases
- high performance liquid chromatography
- mass spectrometry
- tandem mass spectrometry
- clinical trial
- solid phase extraction
- simultaneous determination
- liquid chromatography
- gas chromatography
- drug delivery
- high resolution
- ms ms
- capillary electrophoresis
- randomized controlled trial
- risk assessment
- climate change
- phase ii
- emergency department
- human health
- double blind
- replacement therapy
- study protocol