Association of genetic polymorphisms in the pore domains of mechano-gated TREK-1 channel with overactive lower urinary tract symptoms in humans.

Balachandar NedumaranRicardo H PinedaPratyaydipta RudraSanghee LeeAnna P Malykhina

Published in: Neurourology and urodynamics (2018)

Our results provide evidence that altered expression and function of TREK-1 channel in patients with overactive LUTS could be due to genetic polymorphisms in the pore domains of TREK-1 channel (rs758937019).

Keyphrases

lower urinary tract symptoms
benign prostatic hyperplasia
poor prognosis