A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation.
Jonathan L MettsMatteo TruccoDaniel A WeiserPatrick ThompsonEric SandlerTiffany SmithJessica CrimellaSamer SansilRam ThapaBrooke L FridleyNicholas LlosaThomas BadgettRichard GorlickDamon R ReedJonathan GillPublished in: Cancer medicine (2022)
/day. Radiographic responses were seen in multiple tumor types. Further evaluation for efficacy could be investigated in a Phase II trial.
Keyphrases
- papillary thyroid
- young adults
- acute lymphoblastic leukemia
- acute myeloid leukemia
- study protocol
- childhood cancer
- phase iii
- open label
- squamous cell
- diffuse large b cell lymphoma
- multiple myeloma
- phase ii
- clinical trial
- quality improvement
- atomic force microscopy
- randomized controlled trial
- cerebrospinal fluid
- newly diagnosed
- squamous cell carcinoma
- lymph node metastasis
- high resolution