Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial.

Shinichiro YamadaAtsushi HashizumeYasuhiro HijikataTomonori InagakiDaisuke ItoYoshiyuki KishimotoFumie KinoshitaAkihiro HirakawaShinobu ShimizuTomohiko NakamuraMasahisa Katsuno

Published in: Annals of clinical and translational neurology (2022)

Cold paresis is common and associated with prolongation of distal latency in SBMA. The results of the phase II clinical trial revealed that mexiletine showed short-term safety, but it did not restore cold exposure-induced prolongation of distal latency.

Keyphrases

phase ii
clinical trial
drug induced
open label
minimally invasive
phase iii
high glucose
spinal cord
placebo controlled
diabetic rats
single cell
resistance training
endothelial cells
randomized controlled trial
spinal cord injury
body composition