Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.

Sneha R Rao Alexander L LazaridesBruce L LeckeyWhitney O LaneJulia D VisgaussJason A SomarelliDavid G KirschNicole A LarrierBrian E BrigmanDan G BlazerDiana M CardonaWilliam C Eward

Published in: Cancer medicine (2021)

We have identified three histopathologic characteristics-fibrosis, hyalinization, and infarction-that may serve as predictive biomarkers of response to NRT for STS patients. Future prospective studies will be needed to confirm this association.

Keyphrases

radiation therapy
end stage renal disease
ejection fraction
newly diagnosed
rectal cancer
locally advanced
peritoneal dialysis
lymph node
current status
liver fibrosis
radiation induced