David G Kirsch (David Kirsch)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 42

Top Topics

Top Venues

Nature communications

Cancer research

Molecular cancer therapeutics

This page only lists publications with an associated author ORCID identifier.

Publications

Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis I Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Constantinos Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature communications 15 (1) (2024)
Tona M Gilmer, Chun-Hsiang Lai, Kexiao Guo, Katherine Deland, Kathleen A Ashcraft, Amy E Stewart, Yaode Wang, Jianmin Fu, Kris C Wood, David G Kirsch, Michael B Kastan
A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors. Molecular cancer therapeutics 23 (6) (2024)
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis I Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Constantinos Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature communications 15 (1) (2024)
Peter G Hendrickson, Kristianne M Oristian, MaKenna R Browne, Lixia Luo, Yan Ma, Diana M Cardona, Joshua O Nash, Pedro L Ballester, Scott Davidson, Adam Shlien, Corinne M Linardic, David G Kirsch
Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene 43 (16) (2024)
Tona M Gilmer, Chun-Hsiang Lai, Kexiao Guo, Katherine Deland, Kathleen A Ashcraft, Amy E Stewart, Yaode Wang, Jianmin Fu, Kris C Wood, David G Kirsch, Michael B Kastan
A novel dual ATM/DNA-PK inhibitor, XRD-0394, potently radiosensitizes and potentiates PARP and topoisomerase I inhibitors. Molecular cancer therapeutics (2024)
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis I Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Constantinos Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature communications 15 (1) (2024)
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis I Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Constantinos Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature communications 15 (1) (2024)
Tona M Gilmer, Chun-Hsiang Lai, Kexiao Guo, Katherine Deland, Kathleen A Ashcraft, Amy E Stewart, Yaode Wang, Jianmin Fu, Kris C Wood, David G Kirsch, Michael B Kastan
A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors. Molecular cancer therapeutics 23 (6) (2024)
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis I Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Constantinos Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature communications 15 (1) (2024)
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis I Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Constantinos Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature communications 15 (1) (2024)
Peter G Hendrickson, Kristianne M Oristian, MaKenna R Browne, Lixia Luo, Yan Ma, Diana M Cardona, Joshua O Nash, Pedro L Ballester, Scott Davidson, Adam Shlien, Corinne M Linardic, David G Kirsch
Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene 43 (16) (2024)
Peter G Hendrickson, Kristianne M Oristian, MaKenna R Browne, Lixia Luo, Yan Ma, Diana M Cardona, Joshua O Nash, Pedro L Ballester, Scott Davidson, Adam Shlien, Corinne M Linardic, David G Kirsch
Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene 43 (16) (2024)
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis I Verginadis, Andrea R Daniel, Danielle N Burner, Lucy M Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D Attardi, Constantinos Koumenis, Andy J Minn, Jeffrey L Wrana, Chang-Lung Lee, David G Kirsch
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature communications 15 (1) (2024)
Rutulkumar Patel, Daniel E Cooper, Kushal T Kadakia, Annamarie Allen, Likun Duan, Lixia Luo, Nerissa T Williams, Xiaojing Liu, Jason W Locasale, David G Kirsch
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo. Communications biology 7 (1) (2024)
Peter G Hendrickson, Kristianne M Oristian, MaKenna R Browne, Lixia Luo, Yan Ma, Diana M Cardona, Joshua O Nash, Pedro L Ballester, Scott Davidson, Adam Shlien, Corinne M Linardic, David G Kirsch
Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene (2024)
Peter G Hendrickson, Kristianne M Oristian, MaKenna R Browne, Lixia Luo, Yan Ma, Diana M Cardona, Joshua O Nash, Pedro L Ballester, Scott Davidson, Adam Shlien, Corinne M Linardic, David G Kirsch
Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene (2024)
Rutulkumar Patel, Daniel E Cooper, Kushal T Kadakia, Annamarie Allen, Likun Duan, Lixia Luo, Nerissa T Williams, Xiaojing Liu, Jason W Locasale, David G Kirsch
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo. Communications biology 7 (1) (2024)
Peter G Hendrickson, Kristianne M Oristian, MaKenna R Browne, Lixia Luo, Yan Ma, Diana M Cardona, Joshua O Nash, Pedro L Ballester, Scott Davidson, Adam Shlien, Corinne M Linardic, David G Kirsch
Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene 43 (16) (2024)
Peter G Hendrickson, Kristianne M Oristian, MaKenna R Browne, Lixia Luo, Yan Ma, Diana M Cardona, Joshua O Nash, Pedro L Ballester, Scott Davidson, Adam Shlien, Corinne M Linardic, David G Kirsch
Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene 43 (16) (2024)
Rutulkumar Patel, Daniel E Cooper, Kushal T Kadakia, Annamarie Allen, Likun Duan, Lixia Luo, Nerissa T Williams, Xiaojing Liu, Jason W Locasale, David G Kirsch
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo. Communications biology 7 (1) (2024)
Andrea R Daniel, Chang Su, Nerissa T Williams, Zhiguo Li, Jianguo Huang, Omar M Lopez, Lixia Luo, Yan Ma, Lorraine da Silva Campos, Sara R Selitsky, Jennifer L Modliszewski, Siyao Liu, Rosa Hernansaiz-Ballesteros, Yvonne M Mowery, Diana M Cardona, Chang-Lung Lee, David G Kirsch
Transient knockdown of p53 during focal limb irradiation increases the development of sarcomas. Cancer research communications (2023)
David G Kirsch, Peter Hendrickson, Kristianne Oristian, MaKenna Browne, Lixia Lou, Yan Ma, Dianna Cardona, Corinne Linardic
Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models. Research square (2023)
Wendi Guo, Jiaul Hoque, Carolina J Garcia Garcia, Kassandra V Spiller, Abigail P Leinroth, Vijitha Puviindran, Cahil K Potnis, Kiana A Gunn, Hunter Newman, Koji Ishikawa, Tara N Fujimoto, Denae W Neill, Abagail M Delahoussaye, Nerissa T Williams, David G Kirsch, Matthew J Hilton, Shyni Varghese, Cullen M Taniguchi, Colleen Wu
Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells. Science translational medicine 15 (724) (2023)
Jeffrey L Schaal, Jayanta Bhattacharyya, Jeremy Brownstein, Kyle C Strickland, Garrett Kelly, Soumen Saha, Joshua J Milligan, Samagya Banskota, Xinghai Li, Wenge Liu, David G Kirsch, Michael R Zalutsky, Ashutosh Chilkoti
Brachytherapy via a depot of biopolymer-bound <sup>131</sup>I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours. Nature biomedical engineering 6 (10) (2022)
Rutulkumar Patel, Yvonne M Mowery, Yi Qi, Alex M Bassil, Matthew D Holbrook, Eric S Xu, Cierra S Hong, Jonathon E Himes, Nerissa T Williams, Jeffrey I Everitt, Yan Ma, Lixia Luo, Sara R Selitsky, Jennifer L Modliszewski, Junheng Gao, Sin-Ho Jung, David G Kirsch, Cristian T Badea
Neoadjuvant radiation therapy and surgery improves metastasis-free survival over surgery alone in a primary mouse model of soft-tissue sarcoma. Molecular cancer therapeutics (2022)
Silvia Stacchiotti, Anna Maria Frezza, Jean Yves Blay, Elizabeth H Baldini, Sylvie Bonvalot, Judith V M G Bovée, Dario Callegaro, Paolo G Casali, RuRu Chun-Ju Chiang, George D Demetri, Elisabeth G Demicco, Jayesh Desai, Mikael Eriksson, Hans Gelderblom, Suzanne George, Mrinal M Gounder, Alessandro Gronchi, Abha A Gupta, Rick L M Haas, Andrea Hayes-Jardon, Peter Hohenberger, Kevin B Jones, Robin L Jones, Bernd Kasper, Akira Kawai, David G Kirsch, Eugene S Kleinerman, Axel Le Cesne, Jiwon Lim, María Dolores Chirlaque López, Roberta Maestro, Rafael Marcos-Gragera, Javier Martin Broto, Tomohiro Matsuda, Olivier Mir, Shreyaskumar R Patel, Chandrajit P Raut, Albiruni R A Razak, Damon R Reed, Piotr Rutkowski, Roberta G Sanfilippo, Marta Sbaraglia, Inga-Marie Schaefer, Dirk C Strauss, Kirsten Sundby Hall, William D Tap, David M Thomas, Winette T A van der Graaf, Winan J van Houdt, Otto Visser, Margaret von Mehren, Andrew J Wagner, Breelyn A Wilky, Young Joo Won, Christopher D M Fletcher, Angelo P Dei Tos, Annalisa Trama
Ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities. Cancer 127 (16) (2021)
Amy J Wisdom, David G Kirsch
Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer. Cancer research 80 (24) (2021)
Sneha R Rao, Alexander L Lazarides, Bruce L Leckey, Whitney O Lane, Julia D Visgauss, Jason A Somarelli, David G Kirsch, Nicole A Larrier, Brian E Brigman, Dan G Blazer, Diana M Cardona, William C Eward
Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma. Cancer medicine (2021)
Mark Chen, Joseph P Foster, Ian C Lock, Nathan H Leisenring, Andrea R Daniel, Warren Floyd, Eric Xu, Ian J Davis, David G Kirsch
Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP. Cancer research 81 (19) (2021)
Chang-Lung Lee, Kennedy D Brock, Stephanie Hasapis, Dadong Zhang, Alexander B Sibley, Xiaodi Qin, Jeremy S Gresham, Isibel Caraballo, Lixia Luo, Andrea R Daniel, Matthew J Hilton, Kouros Owzar, David G Kirsch
Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. Cancer research 81 (14) (2021)
Pierre-Benoit Ancey, Caroline Contat, Gael Boivin, Silvia Sabatino, Justine Pascual, Nadine Zangger, Jean Yannis Perentes, Solange Peters, E Dale Abel, David G Kirsch, Jeffrey C Rathmell, Marie-Catherine Vozenin, Etienne Meylan
GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. Cancer research 81 (9) (2021)
Amy J Wisdom, Yvonne M Mowery, Cierra S Hong, Jonathon E Himes, Barzin Y Nabet, Xiaodi Qin, Dadong Zhang, Lan Chen, Hélène Fradin, Rutulkumar Patel, Alex M Bassil, Eric S Muise, Daniel A King, Eric S Xu, David J Carpenter, Collin L Kent, Kimberly S Smythe, Nerissa T Williams, Lixia Luo, Yan Ma, Ash A Alizadeh, Kouros Owzar, Maximillian Diehn, Todd Bradley, David G Kirsch
Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy. Nature communications 11 (1) (2020)
Jianguo Huang, Mohit Sachdeva, Eric Xu, Timothy J Robinson, Lixia Luo, Yan Ma, Nerissa T Williams, Omar Lopez, Lisa D Cervia, Fan Yuan, Xiaodi Qin, Dadong Zhang, Kouros Owzar, Nalan Gokgoz, Andrew Seto, Tomoyo Okada, Samuel Singer, Irene L Andrulis, Jay S Wunder, Alexander J F Lazar, Brian P Rubin, Krista Pipho, Stephano S Mello, Hannah J Wiedner, David G Kirsch
The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways. Molecular cancer research : MCR 18 (10) (2020)
Rebecca D Dodd, Amanda Scherer, Wesley Huang, Gavin R McGivney, Wade R Gutierrez, Emily A Laverty, Kathleen A Ashcraft, Victoria R Stephens, Parisa Yousefpour, Soumen Saha, Vickie Knepper-Adrian, Warren Floyd, Mark Chen, Yan Ma, Eric M Mastria, Diana M Cardona, William C Eward, Ashutosh Chilkoti, David G Kirsch
Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (18) (2020)
Qiang Huang, Malkiel A Cohen, Fernando C Alsina, Garth Devlin, Aliesha D O'Raw, Jennifer McKey, Patrick Havlik, Nikolai Rakhilin, Ergang Wang, Kun Xiang, Parker Mathews, Lihua Wang, Cheryl Bock, Victor A Ruthig, Yi Wang, Marcos Negrete, Chi Wut Wong, Preetish K L Murthy, Shupei Zhang, Andrea R Daniel, David G Kirsch, Yubin Kang, Blanche Capel, Aravind Asokan, Debra L Silver, Rudolf Jaenisch, Xiling Shen
Intravital imaging of mouse embryos. Science (New York, N.Y.) 368 (6487) (2020)
Mark Chen, Eric S Xu, Nathan H Leisenring, Diana M Cardona, Lixia Luo, Yan Ma, Andrea Ventura, David G Kirsch
The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice. Sarcoma 2019 (2019)
Jianguo Huang, Mark Chen, Eric S Xu, Lixia Luo, Yan Ma, Wesley Huang, Warren Floyd, Tyler S Klann, So Young Kim, Charles A Gersbach, Diana M Cardona, David G Kirsch
Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D. Scientific reports 9 (1) (2019)
Nikolai Rakhilin, Aliesha D O'Raw, Chi-Yong Eom, Katherine Ramos Chavez, David M Small, Andrea R Daniel, Melanie M Kaelberer, Menansili A Mejooli, Qiang Huang, Shengli Ding, David G Kirsch, Diego V Bohórquez, Nozomi Nishimura, Bradley B Barth, Xiling Shen
An intravital window to image the colon in real time. Nature communications 10 (1) (2019)
Anthony A Catanzano, David L Kerr, Alexander L Lazarides, Brian L Dial, Whitney O Lane, Dan G Blazer, Nicole A Larrier, David G Kirsch, Brian E Brigman, William C Eward
Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study. Sarcoma 2019 (2019)
Katherine D Castle, David G Kirsch
Establishing the Impact of Vascular Damage on Tumor Response to High-Dose Radiation Therapy. Cancer research 79 (22) (2019)
Amy J Wisdom, Cierra S Hong, Alexander J Lin, Yu Xiang, Daniel E Cooper, Jin Zhang, Eric S Xu, Hsuan-Cheng Kuo, Yvonne M Mowery, David J Carpenter, Kushal T Kadakia, Jonathon E Himes, Lixia Luo, Yan Ma, Nerissa Williams, Diana M Cardona, Malay Haldar, Yarui Diao, Stephanie Markovina, Julie K Schwarz, David G Kirsch
Neutrophils promote tumor resistance to radiation therapy. Proceedings of the National Academy of Sciences of the United States of America 116 (37) (2019)
Amy J Wisdom, Yvonne M Mowery, Richard F Riedel, David G Kirsch
Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma. Cancer 124 (19) (2018)