Inflammatory markers and noncoding-RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle-aged men with prediabetes.
Nikseresht MehdiValiollah Dabidi RoshanKhadijeh NasiriPublished in: Physiological reports (2024)
This study compared the capacity of two different models of HIIT [high-(HC) and low-(LC) compression], with or without the use of berberine (BBR), on NOD-like receptor pyrin domain-containing protein-3 (NLRP3), H19, interleukin (IL)-1β, high-sensitivity C-reactive protein (hs-CRP), and insulin resistance markers. Fifty-four middle-aged men with overweight or obesity and prediabetes [fasting blood glucose (FBG) 110-180 mg/dL] were randomly and equally assigned to the HC, LC, HC + BBR, LC + BBR, BBR, and non-exercising control (CON) groups. The HC (2:1 work-to-rest) and LC (1:1 work-to-rest) home-based training programs included 2-4 sets of 8 exercises at 80%-95% HRmax, twice a week for 8 weeks. Participants in the berberine groups received approximately 1000 mg daily. All exercise interventions led to a significant reduction in hs-CRP, IL-1β, insulin, FBG, and insulin resistance index (HOMA-IR) versus CON. Notably, there was a significant reduction in FBG and HOMA-IR with the BBR group compared to the baseline. Both NLRP3 and H19 experienced a significant drop only with LC in comparison to the baseline. While both exercise protocols were beneficial overall, LC uniquely exhibited more anti-inflammatory effects, as indicated by reductions in H19 and NLRP3. However, the addition of berberine to the exercise programs did not demonstrate additional benefits.
Keyphrases
- insulin resistance
- middle aged
- blood glucose
- high intensity
- simultaneous determination
- physical activity
- type diabetes
- glycemic control
- metabolic syndrome
- mass spectrometry
- weight loss
- high fat diet
- adipose tissue
- liquid chromatography
- public health
- high fat diet induced
- skeletal muscle
- polycystic ovary syndrome
- tandem mass spectrometry
- randomized controlled trial
- blood pressure
- weight gain
- binding protein
- cardiac arrest
- small molecule
- cardiopulmonary resuscitation
- high resolution mass spectrometry
- body composition
- amino acid