The effects of tocotrienols intake on obesity, blood pressure, inflammation, liver and glucose biomarkers: a meta-analysis of randomized controlled trials.
Fengxiang LiBiao XuSamira SoltaniehFernando ZangheliniAhmed Abu-ZaidJian SunPublished in: Critical reviews in food science and nutrition (2021)
The objective of this study is to accomplish a systematic review and meta-analysis of all randomized controlled trials that dissected the influence of tocotrienol supplementation on various anthropometric and cardiometabolic indices in all individuals, irrespective of health condition. This research was carried out in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement guidelines. 17 eligible articles were included in the final quantitative analysis. Current study revealed that tocotrienol consumption was not associated with CRP, WC, MDA, BMI, IL-6, HbA1C, ALT, AST, creatinine TNF-α, FPG, BW, DBP, and SBP. We did observe an overall increase in BW (SMD: 0.063 kg, 95% CI: -0.200, 0.327, p = 0.637) and DBP (SMD: 0.249 mmHg, 95% CI: 0.053, 0.446, p = 0.013). In addition, a significant reduction in SBP was observed (SMD: -0.616 mmHg, 95% CI: -1.123, -0.110, p = 0.017). In summary, our meta-analysis revealed that tocotrienol consumption was associated with increase in BW and DBP and decrease in SBP. Significant associations were not observed for other outcomes.
Keyphrases
- systematic review
- blood pressure
- meta analyses
- healthcare
- randomized controlled trial
- type diabetes
- oxidative stress
- mental health
- insulin resistance
- weight gain
- rheumatoid arthritis
- weight loss
- body composition
- blood glucose
- metabolic syndrome
- social media
- public health
- study protocol
- body mass index
- cell death
- single cell
- health information
- risk assessment
- high fat diet induced
- hypertensive patients
- clinical practice
- cell proliferation
- case control