Longitudinal analysis of microvascular changes in sickle cell disease using swept-source optical coherence tomography angiography.

These longitudinal OCTA findings in sickle cell patients showed an enlargement of the FAZ and a decrease in VD in the temporal and perifoveal regions despite the absence of progression of peripheral retinopathy, suggesting a worsening of the macular non-perfusion over time in sickle cell disease.