Assessment of Clinical Analgesic Levels and Serum Biomarkers in Patients with Rheumatoid Arthritis: A Randomized Controlled Trial Comparing the Efficacy of Diclofenac and Methotrexate Combined Therapy with Extracorporeal Shockwave Therapy.
Mei ZhangZhongyuan MaRinkiko SuguroMenglin ZhuEsther Xinyi ChenXin DongMeixiu ChenLinling ChengBolun SuQiu-Yan ZhangPublished in: Pain research & management (2024)
Both treatments significantly improved joint function, relieved pain, and reduced inflammation in patients. However, ESWT demonstrated a more prominent clinical analgesic effect compared to the combination treatment of diclofenac and MTX. Furthermore, ESWT produced a more immediate and noteworthy anti-inflammatory impact by regulating NRP-1 expression, a trophic factor receptor that facilitates vascular endothelial cell migration and tissue repair through angiogenesis, and regulating RGS-1 to limit inflammatory signal transmission and immune cell activation.
Keyphrases
- anti inflammatory
- cell migration
- neuropathic pain
- end stage renal disease
- oxidative stress
- endothelial cells
- newly diagnosed
- ejection fraction
- poor prognosis
- chronic kidney disease
- chronic pain
- peritoneal dialysis
- stem cells
- high dose
- binding protein
- low dose
- mesenchymal stem cells
- patient reported outcomes
- replacement therapy
- wound healing
- smoking cessation