The handling of missing data in trial-based economic evaluations: should data be multiply imputed prior to longitudinal linear mixed-model analyses?
Ângela Jornada BenJohanna M van DongenMohamed El AliliMartijn W HeymansJos W R TwiskJanet L MacNeil-VroomenMaartje de WitSusan E M van DijkTeddy OosterhuisJudith E BosmansPublished in: The European journal of health economics : HEPAC : health economics in prevention and care (2022)
LLM should be combined with MI when analyzing trial-based economic evaluation data. MI-SUR is more efficient and can also be used, but then an average intervention effect over time cannot be estimated.