Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression.
Stefano MangiolaPatrick McCoyMartin ModrakFernando Souza-Fonseca-GuimaraesDaniel BlashkiRyan StuchberySimon P KeamMichael KergerKen ChowChayanica NasaMelanie Le PageNatalie ListerSimon MonardJustin PetersPhil DundeeScott G WilliamsAnthony J CostelloPaul J NeesonBhupinder PalNicholas D HuntingtonNiall M CorcoranAnthony T PapenfussChristopher M HovensPublished in: BMC cancer (2021)
This study advances our knowledge concerning the role of monocyte-derived recruitment in primary prostate cancer, and supports their key role in disease progression, patient survival and prostate microenvironment immune modulation.