A Single Injection of NTG-101 Reduces the Expression of Pain-Related Neurotrophins in a Canine Model of Degenerative Disc Disease.

Ajay MattaMuhammad Zia KarimHoda GeramiBettina Zoe BenignoIvan ChengArne Mehrkens William Mark Erwin

Published in: International journal of molecular sciences (2022)

= 0.008) relative to PBS injections. Human IVD tissue obtained from spinal surgery due to painful DDD show robust expression of NGFr, BDNF, TrkB and CALCRL proteins. A single intradiscal injection of NTG-101 significantly inhibits the expression of NGFr, BDNF, TrkB and CALCRL proteins in degenerative canine IVDs. These results strongly suggest that NTG-101 inhibits the development of neurotrophins that are strongly associated with painful degenerative disc disease and may have profound effects upon the management of patients living with discogenic pain.

Keyphrases

poor prognosis
chronic pain
pain management
ultrasound guided
endothelial cells
binding protein
minimally invasive
neuropathic pain
long non coding rna
stress induced
intellectual disability
acute coronary syndrome