Pericoronary fat inflammation and Major Adverse Cardiac Events (MACE) in prediabetic patients with acute myocardial infarction: effects of metformin.
Celestino SarduNunzia D'OnofrioMichele TorellaMichele PortogheseFrancesco LoreniSimone MuredduGiuseppe SignorielloLucia ScisciolaMichelangela BarbieriMaria Rosaria RizzoMarilena GaldieroMarisa De FeoMaria Luisa BalestrieriGiuseppe PaolissoRaffaele MarfellaPublished in: Cardiovascular diabetology (2019)
Prediabetes increase inflammatory burden in pericoronary adipose tissue. Metformin by reducing inflammatory tone and leptin to adiponectin ratio in pericoronary fat may improve prognosis in prediabetic patients with AMI. Trial registration Clinical Trial NCT03360981, Retrospectively Registered 7 January 2018.
Keyphrases
- adipose tissue
- acute myocardial infarction
- clinical trial
- oxidative stress
- insulin resistance
- left ventricular
- phase ii
- phase iii
- study protocol
- high fat diet
- percutaneous coronary intervention
- metabolic syndrome
- open label
- fatty acid
- heart failure
- type diabetes
- emergency department
- risk factors
- coronary artery disease
- adverse drug
- electronic health record