Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina.
Carsten BalserAnne WolfMarc HerbThomas LangmannPublished in: Journal of neuroinflammation (2019)
Retinal inhibition of PGF in combination with VEGF-A prevents vascular leakage and CNV possibly via modulating their own expression in mononuclear phagocytes. PGF-related, optimized strategies to target inflammation-mediated angiogenesis may help to increase efficacy and reduce non-responders in the treatment of wet AMD patients.
Keyphrases
- vascular endothelial growth factor
- poor prognosis
- endothelial cells
- diabetic retinopathy
- end stage renal disease
- ejection fraction
- peripheral blood
- newly diagnosed
- chronic kidney disease
- oxidative stress
- optical coherence tomography
- peritoneal dialysis
- signaling pathway
- long non coding rna
- mouse model
- patient reported outcomes