Evaluation of the Effects of Human Dental Pulp Stem Cells on the Biological Phenotype of Hypertrophic Keloid Fibroblasts.
Ming YanLing-Ling FuOla A NadaLi-Ming ChenMartin GosauRalf SmeetsHong-Chao FengReinhard E FriedrichPublished in: Cells (2021)
The co-culture of HDPSCs inhibits the migration of HKFs and the expression of pro-fibrotic genes, while promoting the expression of anti-fibrotic genes. HDPSCs' co-culture also inhibits the synthesis of the extracellular matrix by HKFs, whereas it does not affect the proliferation and apoptosis of HKFs. Therefore, it can be concluded that HDPSCs can themselves be used as a tool for restraining/hindering the initiation or progression of fibrotic tissue.
Keyphrases
- extracellular matrix
- stem cells
- poor prognosis
- systemic sclerosis
- idiopathic pulmonary fibrosis
- endothelial cells
- genome wide
- oxidative stress
- signaling pathway
- binding protein
- endoplasmic reticulum stress
- cell death
- long non coding rna
- gene expression
- cell cycle arrest
- anti inflammatory
- induced pluripotent stem cells
- dna methylation
- mesenchymal stem cells
- pi k akt