Factor VIII concentrate dosing with lean body mass, ideal body weight and total body weight in overweight and obesity: A randomized, controlled, open-label, 3 × 3 crossover trial.
Craig D SeamanJonathan G YabesChristina M LalamaMargaret V RagniPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2021)
Based on our study's findings, overweight and obese patients with haemophilia A may benefit from an individualized PK analysis using LBM and IBW to determine the most accurate, and potentially cost-effective, method of achieving targeted FVIII recovery.