Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial.
David Benjamin AntcliffeKatie L BurnhamFarah Al-BeidhShalini SanthakumaranStephen James BrettCharles J HindsDeborah AshbyJulian C KnightAnthony C GordonPublished in: American journal of respiratory and critical care medicine (2020)
Transcriptomic profile at onset of septic shock was associated with response to corticosteroids. Those with the immunocompetent SRS2 endotype had significantly higher mortality when given corticosteroids compared with placebo. Clinical trial registered with www.clinicaltrials.gov (ISRCTN 20769191).