Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction.
Deana MikhalkovaSujata R HolmanHui JiangMohammed SaghirEric NovakAndrew R CogganRobert O'ConnorAdil BashirAli JamalDaniel S OryJean E SchafferJ Christopher EagonLinda R PetersonPublished in: Obesity (Silver Spring, Md.) (2017)
Surgery-induced weight loss in women with HFpEF and obesity was associated with improved symptoms, reverse cardiac remodeling, and improved relaxation. Although weight loss was associated with plasma sphingolipidome changes, cardiac function improvement was not associated with lipidomic or myocardial triglyceride changes. The results of this study suggest that gastric bypass ameliorates obesity-related HFpEF and that cardiac fat deposition and lipidomic changes may not be critical to its pathogenesis.
Keyphrases
- weight loss
- bariatric surgery
- gastric bypass
- roux en y gastric bypass
- left ventricular
- obese patients
- high glucose
- diabetic rats
- weight gain
- glycemic control
- drug induced
- minimally invasive
- insulin resistance
- adipose tissue
- metabolic syndrome
- heart failure
- coronary artery bypass
- oxidative stress
- fatty acid
- depressive symptoms
- acute coronary syndrome
- single molecule
- atrial fibrillation
- sleep quality
- coronary artery disease
- stress induced