Uncoupled bone remodeling is characteristic of bone damage in premenopausal women with new-onset systemic lupus erythematosus.
Li ZhuJing ZhangJing WangXiaohong LvDan PuYanhua WangQian MenLan HePublished in: Lupus (2021)
Premenopausal patients with new-onset SLE had decreased BMD and abnormal bone metabolism with increased β-CTX and decreased OC and P1NP levels, indicating uncoupled bone remodeling in new-onset SLE patients. Disease activity and abnormal immunity, especially the amount of antibodies in SLE patients, were strongly associated with abnormality of bone metabolism.
Keyphrases
- systemic lupus erythematosus
- disease activity
- bone mineral density
- end stage renal disease
- rheumatoid arthritis
- newly diagnosed
- rheumatoid arthritis patients
- chronic kidney disease
- soft tissue
- peritoneal dialysis
- bone loss
- bone regeneration
- juvenile idiopathic arthritis
- escherichia coli
- oxidative stress
- body composition