N -Allylation of Azoles with Hydrogen Evolution Enabled by Visible-Light Photocatalysis.
Chang-Ming YouCheng HuangSheng TangPeng XiaoShengchun WangZhen-Hong WeiAiwen LeiHu CaiPublished in: Organic letters (2023)
Direct N -allylation of azoles with hydrogen evolution has been achieved through the synergistic combination of organic photocatalysis and cobalt catalysis. The protocol bypasses stoichiometric oxidants and prefunctionalization of alkenes and produces hydrogen (H 2 ) as the byproduct. This transformation highlights high step- and atom-economy, high efficiency, and broad functional group tolerance for further derivatization, which opens a door for C-N bond formation that is valuable in heterocyclic chemistry.
Keyphrases
- visible light
- high efficiency
- ms ms
- randomized controlled trial
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- gas chromatography mass spectrometry
- molecular dynamics
- simultaneous determination
- liquid chromatography
- electron transfer
- cancer therapy
- reduced graphene oxide
- gas chromatography
- tandem mass spectrometry
- water soluble
- ultra high performance liquid chromatography