Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.

Yen-Chun KohShin-Jhih LinKai-Yu HsuNagabhushanam KalyanamChi-Tang HoMin-Hsiung Pan

Published in: Molecular nutrition & food research (2023)

Overall, these findings suggest PSB and PIN as potential candidates for the improvement of obesity and gut microbiota dysbiosis. With its higher stability, PSB exerts a greater effect than PIN by promoting thermogenesis and mitochondrial biogenesis via SIRT1 activation.

Keyphrases

oxidative stress
adipose tissue
insulin resistance
metabolic syndrome
weight loss
ischemia reperfusion injury
high fat diet induced
type diabetes
weight gain
skeletal muscle
signaling pathway
physical activity
body mass index