FUS-CREM-rearranged malignant epithelioid neoplasm mimicking neuroendocrine neoplasm of unknown primary.
Pieter DemetterAhmad AwadPhilippe AftimosGabriel LiberaleChristiane JungelsMaria Gomez-GaldonManuel SaiseletNicolas de Saint AubainPublished in: Histopathology (2021)
A 76-year-old women presented with abdominal pain. Diagnostic investigations suggested peritoneal carcinomatosis. Histological examination of laparoscopic biopsies showed large epithelioid cells forming sheets intermingled with some lymphocytes. There was no clearly distinguishable stroma. Immunohistochemistry showed diffuse and strong expression of cytokeratin AE1/AE3, synaptophysin and chromogranin-A.
Keyphrases
- abdominal pain
- low grade
- induced apoptosis
- poor prognosis
- cell cycle arrest
- polycystic ovary syndrome
- high grade
- robot assisted
- peripheral blood
- endoplasmic reticulum stress
- pregnancy outcomes
- binding protein
- oxidative stress
- cell death
- type diabetes
- skeletal muscle
- signaling pathway
- minimally invasive
- cervical cancer screening