Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery.

Taichi TsuneishiKeiichi KojimaFumika KubotaHideyoshi Harashima Yuma Yamada Yuki Sudo

Published in: Chemical communications (Cambridge, England) (2023)

Light-driven inward proton pump rhodopsin Rm XeR was embedded in pH-sensitive liposomes. Substance release from the proteoliposomes was observed following light illumination both in vitro and in cells, indicating the successful production of light-induced disruptive liposomes (LiDL). Thus, LiDL is a photoswitchable carrier utilized for intracellular substance delivery.

Keyphrases

drug delivery
drug release
induced apoptosis
cell cycle arrest
reactive oxygen species
oxidative stress
cell death
endoplasmic reticulum stress