Toxicity of internal mammary irradiation in breast cancer. Are concerns still justified in times of modern treatment techniques?
Kai Joachim BormCristoforo SimonettoPavel KundrátMarkus EidemüllerMarkus OechsnerMathias DüsbergStephanie Elisabeth CombsPublished in: Acta oncologica (Stockholm, Sweden) (2020)
According to our analyses, the published oncological benefit of IMNI outweighs the estimated risk of cardiac mortality even in case of (e.g., cardiac) risk factors during VMAT. The estimated risk of secondary cancer or pneumonitis attributed to IMNI is low. DIBH reduces the estimated additional risk of IMNI even further and should be strongly considered especially in patients with a high baseline risk.
Keyphrases
- risk factors
- left ventricular
- papillary thyroid
- oxidative stress
- squamous cell
- cardiovascular events
- heart failure
- prostate cancer
- randomized controlled trial
- radical prostatectomy
- systematic review
- radiation therapy
- childhood cancer
- robot assisted
- radiation induced
- combination therapy
- young adults
- rheumatoid arthritis
- minimally invasive
- atrial fibrillation
- breast cancer risk