Current knowledge of protein palmitoylation in gliomas.
Feng TangZhenyuan LiuXi ChenJinzhou YangZefen WangZhiqiang LiPublished in: Molecular biology reports (2022)
Malignant tumor cells can obtain proliferative benefits from deviant metabolic networks. Emerging evidence suggests that lipid metabolism are dramatically altered in gliomas and excessive fatty acd accumulation is detrimentally correlated with the prognosis of glioma patients. Glioma cells possess remarkably high levels of free fatty acids, which, in turn, enhance post-translational modifications (e.g. palmitoylation). Our and other groups found that palmitoylational modification is essential for remaining intracellular homeostasis and cell survival. Disrupting the balance between palmitoylation and depalmitoylation affects glioma cell viability, apoptosis, invasion, self-renew and pyroptosis. In this review, we focused on summarizing roles and relevant mechanisms of protein palmitoylational modification in gliomas.
Keyphrases
- high grade
- fatty acid
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- oxidative stress
- protein protein
- endoplasmic reticulum stress
- amino acid
- cell death
- peritoneal dialysis
- prognostic factors
- binding protein
- cell proliferation
- fluorescent probe
- reactive oxygen species
- signaling pathway
- nlrp inflammasome