STAT3 induces G9a to exacerbate HER3 expression for the survival of epidermal growth factor receptor-tyrosine kinase inhibitors in lung cancers.

Yi-Fang ChangKen-Hong LimYa-Wen ChiangZong-Lin SieJungshan ChangAi-Sheng HoChun-Chia Cheng

Published in: BMC cancer (2019)

The present study revealed that BBI608 could eradicate EGFR-positive lung cancers and demonstrated that STAT3 enhanced the expression of HER3 through miR-145-5p repression by G9a, indicating that STAT3 is a reliable therapeutic target against EGFR-TKI-resistant lung cancers.

Keyphrases

epidermal growth factor receptor
tyrosine kinase
advanced non small cell lung cancer
poor prognosis
cell proliferation
small cell lung cancer
long non coding rna
single cell
chronic myeloid leukemia
young adults