SETDB1 Modulates Degradation of Phosphorylated RB and Anticancer Efficacy of CDK4/6 Inhibitors.
Zhenlin HuangXiang LiBo TangHao LiJianong ZhangRui SunJian MaYunqian PanBinyuan YanYingke ZhouDongling DingYuqian YanRaphael E JimenezJacob J OrmeXin JinJinjian YangZhenlin HuangZhankui JiaPublished in: Cancer research (2023)
The identification of a role for TRIM28 and SETDB1 in regulating CDK4/6-phosphorylated RB stability uncovers a combination strategy using CDK4/6 and SETDB1 inhibition to decrease RB degradation and inhibit cancer growth.