Zhenlin Huang (Haojie Huang, Rui Huang)

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 32

Top Topics

Radical Prostatectomy

Renal Cell Carcinoma

Prostate Cancer

Top Venues

Cancer research

Nature communications

The EMBO journal

EMBO molecular medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Zhenlin Huang, Xiang Li, Bo Tang, Hao Li, Jianong Zhang, Rui Sun, Jian Ma, Yunqian Pan, Binyuan Yan, Yingke Zhou, Dongling Ding, Yuqian Yan, Raphael E Jimenez, Jacob J Orme, Xin Jin, Jinjian Yang, Zhenlin Huang, Zhankui Jia
SETDB1 Modulates Degradation of Phosphorylated RB and Anticancer Efficacy of CDK4/6 Inhibitors. Cancer research 83 (6) (2023)
Hui Zhang, Xiaofeng Jin, Zhenlin Huang
Deregulation of SPOP in Cancer. Cancer research 83 (4) (2023)
Jian Ma, Yingke Zhou, Penglin Pan, Haixin Yu, Zixi Wang, Lei Lily Li, Bing Wang, Yuqian Yan, Yunqian Pan, Qi Ye, Tianjie Liu, Xiaoyu Feng, Shan Xu, Ke Wang, Xinyang Wang, Yanlin Jian, Bohan Ma, Yizeng Fan, Yang Gao, Zhenlin Huang, Lei Li
TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks. Nature communications 14 (1) (2023)
Zhenlin Huang, Xiang Li, Bo Tang, Hao Li, Jianong Zhang, Rui Sun, Jian Ma, Yunqian Pan, Binyuan Yan, Yingke Zhou, Dongling Ding, Yuqian Yan, Raphael E Jimenez, Jacob J Orme, Xin Jin, Jinjian Yang, Zhenlin Huang, Zhankui Jia
SETDB1 Modulates Degradation of Phosphorylated RB and Anticancer Efficacy of CDK4/6 Inhibitors. Cancer research 83 (6) (2023)
Donglin Ding, Alexandra M Blee, Jianong Zhang, Yunqian Pan, Nicole A Becker, L James Maher, Raphael E Jimenez, Liguo Wang, Zhenlin Huang
Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis. Nature communications 14 (1) (2023)
Sandra Santasusagna, Shijia Zhu, Vijayakumar Jawalagatti, Marc Carceles-Cordon, Adam Ertel, Saioa Garcia-Longarte, Won-Min Song, Naoto Fujiwara, Peiyao Li, Isabel Mendizabal, Daniel P Petrylak, William Kevin Kelly, E Premkumar Reddy, Liguo Wang, Matthew J Schiewer, Amaia Lujambio, Robert Jeffrey Karnes, Beatrice Knudsen, Carlos Cordon-Cardo, Haidong Dong, Zhenlin Huang, Arkaitz Carracedo, Yujin Hoshida, Veronica Rodriguez-Bravo, Josep Domingo-Domenech
Master transcription factor reprograming unleashes selective translation promoting castration resistance and immune evasion in lethal prostate cancer. Cancer discovery (2023)
Hui Zhang, Xiaofeng Jin, Zhenlin Huang
Deregulation of SPOP in Cancer. Cancer research 83 (4) (2023)
Jian Ma, Yingke Zhou, Penglin Pan, Haixin Yu, Zixi Wang, Lei Lily Li, Bing Wang, Yuqian Yan, Yunqian Pan, Qi Ye, Tianjie Liu, Xiaoyu Feng, Shan Xu, Ke Wang, Xinyang Wang, Yanlin Jian, Bohan Ma, Yizeng Fan, Yang Gao, Zhenlin Huang, Lei Li
TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks. Nature communications 14 (1) (2023)
Jinge Zhao, Sha Zhu, Ling Nie, Meng-Ni Zhang, Linmao Zheng, Nanwei Xu, Diming Cai, Xiaomeng Sun, Junru Chen, Jindong Dai, Yuchao Ni, Zhipeng Wang, Xingming Zhang, Jiayu Liang, Yuntian Chen, Xu Hu, Xiuyi Pan, Xiaoxue Yin, Haoyang Liu, Fengnian Zhao, Bei Zhang, Hao Chen, Jiashun Miao, Cong Qin, Xiaochen Zhao, Jin Yao, Zhenhua Liu, Banghua Liao, Qiang Wei, Xiang Li, Zhenhua Liu, Allen C Gao, Zhenlin Huang, Peng-Fei Shen, Ni Chen, Hao Zeng, Guangxi Sun
Genomic and Evolutionary Characterization of Concurrent Intraductal Carcinoma and Adenocarcinoma of the Prostate. Cancer research (2023)
Rui Sun, Binyuan Yan, Hao Li, Dongling Ding, Liguo Wang, Jun Pang, Dingwei Ye, Zhenlin Huang
Androgen receptor variants confer castration resistance in prostate cancer by counteracting antiandrogen-induced ferroptosis. Cancer research (2023)
Hui Zhang, Xiaofeng Jin, Zhenlin Huang
Deregulation of SPOP in Cancer. Cancer research 83 (4) (2023)
Zhenlin Huang, Xiang Li, Bo Tang, Hao Li, Jianong Zhang, Rui Sun, Jian Ma, Yunqian Pan, Binyuan Yan, Yingke Zhou, Dongling Ding, Yuqian Yan, Raphael E Jimenez, Jacob J Orme, Xin Jin, Jinjian Yang, Zhenlin Huang, Zhankui Jia
SETDB1 modulates degradation of phosphorylated RB and anti-cancer efficacy of CDK4/6 inhibitors. Cancer research (2023)
Kirsten G M Aspros, Jodi M Carter, Tanya L Hoskin, Vera J Suman, Malayannan Subramaniam, Michael J Emch, Zhenqing Ye, Zhifu Sun, Jason P Sinnwell, Kevin J Thompson, Xiaojia Tang, Esther P B Rodman, Xiyin Wang, Adam W Nelson, Igor Chernukhin, Feda H Hamdan, Elizabeth S Bruinsma, Jason S Carroll, Martin E Fernandez-Zapico, Steven A Johnsen, Krishna R Kalari, Zhenlin Huang, Roberto A Leon-Ferre, Fergus J Couch, James N Ingle, Matthew P Goetz, John R Hawse
Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer. NPJ breast cancer 8 (1) (2022)
Hui Zhang, Xiaofeng Jin, Zhenlin Huang
Deregulation of SPOP in cancer. Cancer research (2022)
Donglin Ding, Rongbin Zheng, Ye Tian, Raphael E Jimenez, Xiaonan Hou, Saravut J Weroha, Liguo Wang, Lei Shi, Zhenlin Huang
Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer. Nature communications 13 (1) (2022)
Yuqian Yan, Jingwei Shao, Donglin Ding, Yunqian Pan, Phuc Tran, Wei Yan, Zhengyu Wang, Hong-Yu Li, Zhenlin Huang
3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O'PROTAC. Chemical communications (Cambridge, England) 58 (14) (2022)
Alastair Davies, Shaghayegh Nouruzi, Dwaipayan Ganguli, Takeshi Namekawa, Daksh Thaper, Simon Linder, Fatih Karaoğlanoğlu, Meltem E Omur, Soojin Kim, Maxim Kobelev, Sahil Kumar, Olena Sivak, Chiara Bostock, Jennifer Bishop, Marlous Hoogstraat, Amina Talal, Suzan Stelloo, Henk van der Poel, Andries M Bergman, Musaddeque Ahmed, Ladan Fazli, Zhenlin Huang, Wayne D Tilley, David Goodrich, Felix Y Feng, Martin Gleave, Housheng Hansen He, Faraz Hach, Wilbert Zwart, Himisha Beltran, Luke A Selth, Amina Zoubeidi
An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer. Nature cell biology 23 (9) (2021)
Dejie Wang, Jian Ma, Maria Victoria Botuyan, Gaofeng Cui, Yuqian Yan, Donglin Ding, Yingke Zhou, Eugene W Krueger, Jiang Pei, Xiaosheng Wu, Liguo Wang, Huadong Pei, Mark A McNiven, Dingwei Ye, Georges Mer, Zhenlin Huang
ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication. Science advances 7 (25) (2021)
Lei Shi, Yuqian Yan, Yundong He, Binyuan Yan, Yunqian Pan, Jacob J Orme, Jun Zhang, Wanhai Xu, Jun Pang, Zhenlin Huang
Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression. Cancer research 81 (13) (2021)
Guangxi Sun, Xingming Zhang, Jiayu Liang, Xiuyi Pan, Sha Zhu, Zhenhua Liu, Cameron M Armstrong, Jianhui Chen, Wei Lin, Banghua Liao, Tianhai Lin, Zhenlin Huang, Mengni Zhang, Linmao Zheng, Xiaoxue Yin, Ling Nie, Peng-Fei Shen, Jinge Zhao, Haoran Zhang, Jindong Dai, Zhiping Li, Junru Chen, Zhipeng Wang, Xudong Zhu, Yuchao Ni, Dan Qin, Ling Yang, Yuntian Chen, Qiang Wei, Xiang Li, Qiao Zhou, Jin Yao, Ni Chen, Hao Zeng
Integrated Molecular Characterization of Fumarate Hydratase-deficient Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (6) (2021)
Jianong Zhang, Kun Gao, Hongyan Xie, Dejie Wang, Pingzhao Zhang, Ting Wei, Yuqian Yan, Yunqian Pan, Wenbin Ye, Huifen Chen, Qing Shi, Yao Li, Shi-Min Zhao, Xiaonan Hou, Saravut J Weroha, Yuzhuo Wang, Jun Zhang, R Jeffrey Karnes, Housheng Hansen He, Liguo Wang, Chenji Wang, Zhenlin Huang
SPOP mutation induces DNA methylation via stabilizing GLP/G9a. Nature communications 12 (1) (2021)
Jingwei Shao, Yuqian Yan, Donglin Ding, Dejie Wang, Yundong He, Yunqian Pan, Wei Yan, Anupreet Kharbanda, Hong-Yu Li, Zhenlin Huang
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (20) (2021)
Marieke Burleson, Janice J Deng, Tai Qin, Thu Minh Duong, Yuqian Yan, Xiang Gu, Debodipta Das, Acarizia Easley, Michael A Liss, P Renee Yew, Roble Bedolla, Addanki Pratap Kumar, Tim Hui-Ming Huang, Yi Zou, Yidong Chen, Chun-Liang Chen, Zhenlin Huang, Lu-Zhe Sun, Thomas G Boyer
GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer. Molecular cancer research : MCR (2021)
Jian Ma, Qing Shi, Gaofeng Cui, Haoyue Sheng, Maria Victoria Botuyan, Yingke Zhou, Yuqian Yan, Yundong He, Liguo Wang, Yuzhuo Wang, Georges Mer, Dingwei Ye, Chenji Wang, Zhenlin Huang
SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. Nature communications 12 (1) (2021)
Guangxi Sun, Junru Chen, Jiayu Liang, Xiaoxue Yin, Mengni Zhang, Jin Yao, Ning He, Cameron M Armstrong, Linmao Zheng, Xingming Zhang, Sha Zhu, Xiaomeng Sun, Xiaoxia Yang, Wanbin Zhao, Banghua Liao, Xiuyi Pan, Ling Nie, Ling Yang, Yuntian Chen, Jinge Zhao, Haoran Zhang, Jindong Dai, Yali Shen, Jiyan Liu, Rui Huang, Jiandong Liu, Zhipeng Wang, Yuchao Ni, Qiang Wei, Xiang Li, Qiao Zhou, Zhenlin Huang, Zhenhua Liu, Peng-Fei Shen, Ni Chen, Hao Zeng
Integrated exome and RNA sequencing of TFE3-translocation renal cell carcinoma. Nature communications 12 (1) (2021)
Zhenlin Huang, Bo Tang, Yinhui Yang, Zhaogang Yang, Lei Shi, Yang Bai, Binyuan Yan, R Jeffrey Karnes, Jun Zhang, Rafael Jimenez, Liguo Wang, Qiang Wei, Jinjian Yang, Wanhai Xu, Zhankui Jia, Zhenlin Huang
MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression. Cancer research 81 (17) (2021)
Yundong He, Ting Wei, Zhenqing Ye, Jacob J Orme, Dong Lin, Haoyue Sheng, Ladan Fazli, R Jeffrey Karnes, Raphael E Jimenez, Liguo Wang, Liewei Wang, Martin E Gleave, Yuzhuo Wang, Lei Shi, Zhenlin Huang
A noncanonical AR addiction drives enzalutamide resistance in prostate cancer. Nature communications 12 (1) (2021)
Yingke Zhou, Xin Jin, Jian Ma, Donglin Ding, Zhenlin Huang, Haoyue Sheng, Yuqian Yan, Yunqian Pan, Ting Wei, Liguo Wang, Heshui Wu
HDAC5 Loss Impairs RB Repression of Pro-Oncogenic Genes and Confers CDK4/6 Inhibitor Resistance in Cancer. Cancer research 81 (6) (2021)
Yuqian Yan, Jian Ma, Dejie Wang, Dong Lin, Xiaodong Pang, Shangqian Wang, Yu Zhao, Lei Shi, Hui Xue, Yunqian Pan, Jun Zhang, Claes Wahlestedt, Francis J Giles, Yu Chen, Martin E Gleave, Collin C Collins, Dingwei Ye, Yuzhuo Wang, Zhenlin Huang
The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer. EMBO molecular medicine 11 (11) (2019)
Yu Zhao, Liya Ding, Dejie Wang, Zhenqing Ye, Yundong He, Linlin Ma, Runzhi Zhu, Yunqian Pan, Qiang Wu, Kun Pang, Xiaonan Hou, Saravut J Weroha, Conghui Han, Roger Coleman, Ilsa Coleman, R Jeffery Karnes, Jun Zhang, Peter S Nelson, Liguo Wang, Zhenlin Huang
EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis. The EMBO journal 38 (5) (2019)
Yuqian Yan, Jian An, Yinhui Yang, Di Wu, Yang Bai, William Cao, Linlin Ma, Junhui Chen, Zhendong Yu, Yundong He, Xin Jin, Yunqian Pan, Tao Ma, Shangqian Wang, Xiaonan Hou, Saravut John Weroha, R Jeffrey Karnes, Jun Zhang, Jennifer J Westendorf, Liguo Wang, Yu Chen, Wanhai Xu, Runzhi Zhu, Dejie Wang, Zhenlin Huang
Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer. EMBO molecular medicine 10 (4) (2019)
Chun-Wu Pan, Xin Jin, Yu Zhao, Yunqian Pan, Jing Yang, R Jeffrey Karnes, Jun Zhang, Liguo Wang, Zhenlin Huang
AKT-phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1-MAPK interaction. The EMBO journal 36 (8) (2017)