Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised controlled trial.
Thomas E WilliamsCarmen TurArman EshaghiAnisha DoshiDennis ChanSophie BinksHenny WellingtonAmanda HeslegraveHenrik ZetterbergJeremy ChatawayPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2022)
Elevated sNfL is associated with faster cognitive decline, independent of T2LV and regional normalised volumes.
Keyphrases
- cognitive decline
- multiple sclerosis
- mild cognitive impairment
- white matter
- study protocol
- magnetic resonance imaging
- contrast enhanced
- mass spectrometry
- cerebrospinal fluid
- cell proliferation
- computed tomography
- randomized controlled trial
- clinical trial
- magnetic resonance
- diffusion weighted imaging
- data analysis