Model-Based Estimation of Iohexol Plasma Clearance for Pragmatic Renal Function Determination in the Renal Transplantation Setting.
Tom C ZwartAiko P J de VriesAline G J EngbersRuth E DamPaul J M van der BoogJesse J SwenRon J KeizerR Neil DaltonHenk-Jan GuchelaarJohan W de FijterDirk Jan A R MoesPublished in: Clinical pharmacokinetics (2021)
Our online pharmacometric tool provides an accurate, pragmatic, and ready-to-use technique for measured GFR-based renal function evaluation for clinical situations where conventional methods lack accuracy or show limited feasibility. Additional adaptation and validation of our model and limited sampling schedules for renal transplant recipients with GFRs below 30 mL/min is warranted before considering this technique in these patients.