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Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson's disease models.

Andrea AntonosanteVanessa CastelliMartina SetteMargherita AlfonsettiMariano CatanesiElisabetta BenedettiMatteo ArdiniAnnamaria CiminiMichele D'Angelo
Published in: Biological research (2023)
In summary, PPARβ/δ antagonist displayed neuroprotective activities against 6-hydroxydopamine detrimental effects both in vitro and in vivo models of Parkinson's disease, suggesting that it may represent a novel therapeutic approach for this disorder.
Keyphrases
  • insulin resistance
  • signaling pathway
  • pi k akt
  • fatty acid