Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson's disease models.
Andrea AntonosanteVanessa CastelliMartina SetteMargherita AlfonsettiMariano CatanesiElisabetta BenedettiMatteo ArdiniAnnamaria CiminiMichele D'AngeloPublished in: Biological research (2023)
In summary, PPARβ/δ antagonist displayed neuroprotective activities against 6-hydroxydopamine detrimental effects both in vitro and in vivo models of Parkinson's disease, suggesting that it may represent a novel therapeutic approach for this disorder.