Helicobacter pylori ( H. pylori ) infection is chronic and etiologically linked to gastric cancer (GC) derived from gastric epithelium. The potential mechanism is complex, covering chronic inflammation, epithelial senescence, NF- κ B activation, the cytotoxin-associated gene A protein translocation, and related abnormal signaling pathways. In clinical practice, the test-and-treat strategy, endoscopy-based strategy, and (family-based) screen-and-treat strategy are recommended to detect H. pylori and prevent GC. It has been demonstrated that the decreasing annual incidence of GC is largely attributable to the management of H. pylori . This study reviews the current clinical practice of H. pylori on the detection and eradication, alternative treatment strategies, and related problems and advances, and hopes to contribute to the better clinical management of H. pylori .
Keyphrases
- helicobacter pylori
- helicobacter pylori infection
- clinical practice
- signaling pathway
- mental health
- loop mediated isothermal amplification
- risk factors
- gas chromatography
- real time pcr
- dna damage
- systematic review
- gene expression
- genome wide
- randomized controlled trial
- binding protein
- small molecule
- protein protein
- transcription factor
- nuclear factor
- quantum dots
- induced apoptosis
- combination therapy
- epithelial mesenchymal transition
- tandem mass spectrometry
- human health
- climate change
- endoplasmic reticulum stress
- smoking cessation