High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer.

Sören A WeidemannCharlotte SauerAndreas M LuebkeChristina Möller-KoopStefan SteurerClaudia Hube-MaggFranziska BüscheckDoris HöflmayerMaria Christina TsourlakisTill S ClauditzRonald SimonGuido SauterCosima GöbelPatrick LebokDavid DumChristoph FrauneSimon KindSarah MinnerJakob IzbickiThorsten SchlommHartwig HulandHans HeinzerEike BurandtAlexander HaeseMarkus GraefenAsmus Heumann

Published in: BMC cancer (2019)

These data identify PTPN12 as an independent prognostic marker in prostate cancer. PTPN12 analysis, either alone or in combination with other biomarkers might be of clinical utility in assessing prostate cancer aggressiveness.

Keyphrases

prostate cancer
poor prognosis
radical prostatectomy
long non coding rna
binding protein
electronic health record
big data
small molecule
artificial intelligence
amino acid
data analysis
protein protein