Roles of NADPH oxidase and mitochondria in flow-induced vasodilation of human adipose arterioles: ROS-induced ROS release in coronary artery disease.
Natalya S ZinkevichIbra S FancherDavid D GuttermanShane A PhillipsPublished in: Microcirculation (New York, N.Y. : 1994) (2018)
These findings indicate that ROS produced by NADPH oxidase are an upstream component of the mitochondria-dependent pathway contributing to flow-dependent H2 O2 generation and dilation in peripheral microvessels from patients with CAD. We conclude that in CAD, both mitochondria and NADPH oxidase contribute to FID through a redox mechanism in visceral arterioles.
Keyphrases
- coronary artery disease
- reactive oxygen species
- cell death
- high glucose
- endothelial cells
- dna damage
- diabetic rats
- insulin resistance
- percutaneous coronary intervention
- cardiovascular events
- drug induced
- coronary artery bypass grafting
- type diabetes
- heart failure
- metabolic syndrome
- transcatheter aortic valve replacement
- pluripotent stem cells
- ejection fraction