Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma.
Darya S NesterovaVishal MidyaBrad E ZachariaElizabeth A ProctorSang Y LeeLindsay C StetsonJustin D LathiaJoshua B RubinKristin A WaiteMichael E BerensJill S Barnholtz-SloanJames R ConnorPublished in: Neuro-oncology advances (2020)
The level of HFE expression in GBM has a sexually dimorphic impact on survival. Whereas HFE expression below the median imparts a survival benefit to females, high HFE expression is associated with significantly worse overall survival regardless of established prognostic factors such as sex or MGMT methylation.