Proton and photon radiosensitization effects of niraparib, a PARP-1/-2 inhibitor, on human head and neck cancer cells.
Li WangJianzhong CaoXiaochun WangEric LinZeming WangYuting LiYupeng LiMei ChenXianliang WangBo JiangRuiping ZhangNarayan SahooXiaodong ZhangX Ronald ZhuJeffrey N MyersSteven J FrankPublished in: Head & neck (2020)
Niraparib enhanced the sensitivity of four HNSCC cell lines to both photons and protons and increased the RBE of protons, possibly by inhibiting DDR. Niraparib may enhance the effectiveness of both photon and proton radiotherapy for patients with HNSCC.