Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study.

Denise VisserSander C J VerfaillieIris BoschIman BrouwerHayel TuncelEmma M CoomansRoos M RikkenSophie E MastenbroekSandeep S V GollaFrederik BarkhofElsmarieke van de GiessenBart N M van BerckelWiesje M van der FlierRik Ossenkoppele

Published in: European journal of nuclear medicine and molecular imaging (2023)

We showed that higher tau load was related to accelerated cortical thinning, but not to decreases in relative CBF. Moreover, tau PET load at baseline was a stronger predictor of cortical thinning than change of tau PET signal.

Keyphrases

cerebrospinal fluid
cerebral blood flow
computed tomography
pet ct
positron emission tomography
high resolution
pet imaging
photodynamic therapy