Targeting Breast Cancer with N-Acetyl-D-Glucosamine: Integrating Machine Learning and Cellular Assays for Promising Results.
Ömür BaysalDeniz GençRagıp Soner SilmeKevser Kübra KırboğaDilek ÇobanNaeem Abdul GhafoorLeyla TekinOsman BulutPublished in: Anti-cancer agents in medicinal chemistry (2024)
Our study demonstrated the positive effect of D-GlcNAc administration on breast cancer cells, leading to increased apoptosis and Fas expression in the malignant phenotype. The binding affinity of D-GlcNAc to HER2 suggests a potential mechanism of action. These findings contribute to understanding D-GlcNAc as a potential anti-tumour agent for breast cancer treatment.