Photoredox-Catalyzed Acylchlorination of α-CF 3 Alkenes with Acyl Chloride and Application as Masked Access to β-CF 3 -enones.

We disclose a photocatalytic strategy that simultaneously addresses the construction of trifluoromethylated quaternary carbon centers and the preparation of β-CF 3 -enones through radical difunctionalization of α-CF 3 alkenes with acyl chlorides. This method is characterized by its broad functional group compatibility, high efficiency, and atom economy. The versatility of this transformation is poised to broaden the applications of α-CF 3 alkenes, providing new pathways for the rapid assembly of structurally diverse fluorinated compounds.